UCSF NMR1HCC(>@oD1H~~CC@nDtZZY(Dꅪ31&$ibŃE{FZETM ŏň3E\MFEIēF4IF5G "FuFKcF|({GG}GFz_åHn؟DPD{Mö?DE`) EO=AyŽ.xeśC@j8K,oBE+^E|FFF3C ;2qW"EdR"[_ FcuFEofEciEF9E{JEl\ݤxǗ4$1BǪ'ǿO̦0UO{})Ǧǝrg rŇE[+E;ExhE3UEY,DեtÂD@TElE@EXYŖlAϜE/,Dľp ňJœ;ĪmݽqLD/֚JƁlzʇEEE3xDEпE,EEAűp >*ŞRâ\hoٛŵ- %&D%Ek`IjCE|YEsF'G'FE ED[pEFIFFDFj7FGЩG)%F%E[E?vEEEIEZE9XE5=D_b7ŨzŏƓْS'eDVE”F &F;eF|Eēl#l@EGMnǿN,a;B2FdDLEEE Cо(D'bOn%Ƌ(EG4S B:=ܰǁϙǞHQ R5ǓǺǓP;jmƝE6E[KďwE_+EpE/En2DODJEOEEr.DBO/ExEdTE~E]4Ep.rŤSDEYpE5:cſśBWT^k*#E?EJEG*F,F=E1 4#i)lDŅӠkő@))@ ő]3Iņ+ND".F F6!|đ EcESF&%F ?E̛FhFFFʍFP"F DOsDEF FCbBF)ERXĆ #śTŮD[lĿ`VEz EǫAEuᓵŎtRBE?;×ǝ6+CF k( FfǖFeSFPųUDb[BrR+7feVƈg+ƾ Ǒo.c̰SvgpKǝ‹Ny7[.ǟHUǎA)PFR>EYDQEh=DsDB Y|EFy"FYEEEEF/.F)ESEECiþJEO?EPEiD5EBETzJz(ś{EɩEbK(EݙFQs[F;C99&k%>1łū:ZŚFo#EmE+Wţ_D;4Ef%EMEĂ"~\'CCE0hED\q)YESyEذ]E@g ǐ[Ď`EF F#D‘3!œqħI )ENFOF!^EȘŊ647&Iū7Ǜ'ǦuF3' <@.Gc FcJ*"mŗaBnEE5D QƇiǚV 9)f\SZǺLKYOퟖǁ^g#C$ǁwǫzhrvĄFaCEoZDE9D$Ų'/EŝÞ0HŊbĩt9CE F FJ{E)WŬA׈EPE̷D6BafDEeEQEEE$E$DxE.EHEvi4q_5EEVDu(|D EAME¦Fk!Expb DfSGC]DbF/F*`FiEh>Ňt8Lyiŏǁh}FmƉV/XƺCGAFDAE[EFf=Fc7 C ƁNJL"r=\pKkmI צnܕ2h7S OdFAuNJ#C7,_qEŲşdE)@Sb'ĽKnYE(:FF D\oL"-CuEHNtVń EDO&{D|DVrŻ{.4JE2ĎٕzS'&_E/sxz0D#EW_&EDwEmEwEEuEp:E-`ED]2\ŢU/łDXDE)E &Ee2EnE-EKEòrCtEEEZC)DEQyWE0EMEgUEBEEEDFDuZEn&FiDQFR4F|&F,]ETōpUEw;E2L~=G,@]՝Ǽ G'GGF6/vFY$6FS1 F,ELVщ%_btC ǾR8H |pO[Ǐ!ǂƗdI|>Y>f3E$FE&ŋ/3O$ųCeEl 1DDē4ftqnŢ@ŕOħīDňegkEWDDqED_DI0E8<*ħ 6E.EwOELE; Āsϛ}߄DřX+DEEړE&^EMmC<Cń/Ő D,EEDF#lFEDzDNEkE9?EBiEذE D(DG:bkĩ5$EV5E̵EDNZSDE E~FSFGF[F FϧEuŜDiFP~F={HzFSGe7=܏lǐGG~!GF"Fg^FcVEE.UOſsųr'Pl D,#`p @ňogDDD!EtZ!gŏdD_ME}1EaM5EZN1DюŏxqnsR4EELSD/DEYEoAŝo ſ=ŌؤŸXTEDyGE#{;EEШcEXD:ENEXEjFFFM"D0āzDEn3E˱EQ5EEE\KņKXsE!'F "yFG4G.@gG(ljGKF?F>F`pF?fa*aP%&œ =&TU <|G[GmFsG6JEGGu7GKFW<FGGZGxHGAFQz4 c<őU`v\ńY^E$D A"6`RiE$wTay#X`ll&D-Eņ տűqBM&ç6DLd6DF}Ŀ(D Qz3 EcEU+EC&\RāEeD$ȧ99kaXBsVB)OEgEMkF0tE}GATiDl E;FFTFkEYyEFzKFnKF2`EyEn1 ?;CEH)E(CњpDǷEFF[FFF䘠FGG%UGjGIGL[GFïfQCF֤rGcŤH'HVG#=oeći%!qƞE6ƚS_ƍ /k ]hGpG}GFAOFbGg1FrưgY IoŠGcLGMFN7w dBj{ŕ< DVSEGE2kEvE >ĮEE̙EE~W_aŀO M"WDݫ&!F|5mō]^ŹĶfE_EXRD?=P>UDtHFEq(z5fbSq1//>K8}|59*%ŕ9CoEBFDN{TGr0]aF~rFLEG@QFFƲz~ UE[FG<kGrIcYJ.;%JR@SI46Hv+I*JyJsI.H3HH G G G^lGƑ HOH;I0wIͿzJ OJ1&Jc6JMx=JJJL.JN)J)uJLIJ3JP%I/IH]GOG^"AGyG0G/G/6HG#5G EF]F>FhjFTFYGGԟGGuF2$FFFjEFisFf3F5BEEYFF FFkEhE F^RF<E|CeE TZaY6TP>S[rTD,.#/q>MY2 R&7/$?y*e6h>:F>0Q:b4z7_QnEqM|li+vSrrLJ!ǑǔNJ'DŽrDŽdžǁ]a\HPgVRW5W~ZLJ[ ;IJJ IJ5IMJ0(J,JIhH3HB]HZ[HUgG>GH^jHsH>I@@J(ߑJxDJadJIJ&JoJ{JeJYJJH;J.˭J^wJkýJ9EIRI7RHECH!pGڿGKoG ;GiGGnmGTBGC!G%UG*4+G["UGa3GSuGkCGץGcG2iGFFݨFF03FKFNdFT6FF-FPF|nE!E F_OFF?FzE] EwcCQm^"sOr MP]awd`M‡`nkkUq#`:[AUIfNhUmj1tGnx,cvtm*Dž1eǒ{ǍvyǁLJ+Ǔǔǒ+8ǖ|Ǩ*ǸQǷ pǨǡ(ǜFǛkǖDŽqxBǀ_rxϿE7rOy)AS*%`EiZ;`IZKW@6A9($jƿrƒM:SFáFUFİIT4J:)Jo/_IPH&0I8 J?JuJHNHjKH!GmFEWGuRHNSH<;I>J!Jq~+JJv`JSJC5aJB]JvBJofwJ::J IJ"y*J1RJ I&$IGԆGVGpaGrF/GiQ)G_G9GcG]FtdGGG GG G8]G>0G+G&Y G4F!fFFaYFNFS[FSqFd'FO" F%,F&&ESEEDF$XF,6mF&FruE= DD+cǏ}4BEE BDŽŹx z~"%ņ?Ŭ(1{Y.VYP0F,t& Wukb(Xc(-޾!D,CĞ ]ō! )2Iŷi\Ŧ]Ŷ*}E>EŧFF/zF`FʫGF=GXHoLIH1.G qI"IItHG\GJ[`GG FFkԄGgGS8GcH'I2IdIdIoI ƸHmII!I p>HH I gI!kH}UHGF>FDFiFF%EAĤvz}aʼnv ED8Ű2DD YF)E-4O>Ńi}ň ŵM,)XCoŻވśŅD1[D!Xb' :=#Cm./X{Ƙ=rCF HI!lḪ GIH@I6|I`YHȫFh{EG`]GkGFpFePF΄G~G~HIzIZIC_Ij\H4H}I~JI nI7HuHHHd H 8H uHGIG =Fň=FxFlF ~EE7H(KBEEmE朡Bd~ż\`?UevE"EE+F*6E\E$E=DcDD]bĄ)E,FC DDU8ĔElFDE >ŭ\F97ƫƵBhpPƼ rƪmƜ9Ƣ =ߟƩvƼDU! JUưQƫ0 T ƳXԩ; mƍ×ƕPg .&ib5Aq:< *s6]VJnJJJ)FJIIIXSI6IDICxImVOIHqcH֮G_Gv6GTG/fG *FFF, FdFZFFFF/FΟFxFnF:F(FrF!F8FʅE㬷E*ŏcdCV5D^ĖEkE~đşCU0a.`?L.D%6 3g27V3(@6#UAb^e~V?H-RArvmwbhVV81 Per@A>Hw{'yNJǟǪmǣTǞ2ǤoIǫ8VǪ3ǪoǯKDZ~Ǧǀ7V'>J~\J|WJJJZJ)1J*bJO+'JEJIߐIj-lHFHK1H;GGG%=GOGeGjGeGZbGM:G1G&G6p@G&=GrG FhPF GGFq#FFIF7LF6FFFT@EEkaF=(Fo:Em_E.eD2ଋ%VyO.L\LgJW;AF?@DI3(A*5FU4g|r_g3PU#ge"y2rod^yWcwlUg2N,ItAǔǐLjNJͪǕǩǰIǫ(ǧmǨ#ǡ_Ǟ'ǩ*=Ǵ-ǹMǤLJPTSs]|IMmJ̬JJ0I5_JCJMJ\ J*SZHJQHaaHNGRF:i;FbHhh_H˱IKJnJ7JK J۸JJJԜJxJn`*J0J-jQJP]JSJ4}_J+I~yHHk&PHq)GQG[GGGG TGsGiVG[GGhGIJpGRG< G-UG,#G!6KGG {G 'EGFAFoFuF+eF.HFFjFFcF^YFKsEE`"ķ͘JѩJJJ\J'AJ*gFJCT JFJ3J~ImHeH. G@zG&GGG{8GyX6`57N#Am]:num`ԢUl,~*}]iפQ%= f)S1<3Ƨ}ǑǠǜ!3EXGLtIJ^UJFIrH57J3JJ&G:GKZG8D*GM GG F*rFFYFF2FByF3W-FxFnF7wEE1IEcoF'F&qF)^>ELĔVG N+s[9˪gq$?И' -ձ)*Qւx 8%bV1m5 )&188]H?>PG%/^[ƦDV3a+1!/Һ5?t6^`ǃaǎnhƱE?IV)J2|JU}(IOLG}IcJ˥JP J 6HHuKH]HuGpFoGyGHHIBbJ J[=JJ?Jx}JJJP0RJ@JuII J 0JII]IsHJH#G嶍GG{GWsG6)GG*G FAFkFGlGGFGFBFB FмFBGGYGF FBvFdFK FF*ĞţDDHF+HF0RE9 E E$Îƅ[qwtLƏ6Əƃ ^QW_Ƥ^ƾƏƃllxy/DƒƟn+,.TO 6ƅeƇWcw9ƇDSƚfƢ8ƝƑCtƖQ ƫ%==~vnf0ƵƠƱƻƢ'Ɵ1ƭXFƩiƣJƿ6 (T)9H)HU{IwIIU~GI,JuJkXInHE6GGܢ$GFWSF NGHGp0HcIHIJJ$FJIIu_IIfIZ$I%XI3IVIfAIYiXI-5H$HGƈG0CGSoG FFԋWFaF:FPeF4RiFñFWFchFQFFFtFN5F3=FjFNF}FrF!FFحtF߅FE5 E#F!1EOCctʡI:Ŀ9ĩºOŢpÐ,t avŎgŧ3hċExE'JDXEF.G6EМuDC_rD)"EXEYEV1DGLJC%D"DG/E8Ő`Hq".NjV'ŊgOĞ'f%őCXLų{Ɔ-k DǺ??rHŰŕ(Chĕ@S6^~AlĀE*:Xź)- `p7Ńv8[ d"ſƀS,gQ:iƋ+fƒƟ hKǻ]GVS"ERiȚYQGXpFilw(&E WiBŮfdԡ2HЬȀ<[bw ՞,g~׊ǏjǢc jW|ƫF^FFFFTF9FcLFDcEZEܒEF0oFGz4ED^Aő2E]ֽF)~EE=EEEWEETrEF9sFEԹkľx]RhE/=ENԲDEE^D(9jøzEO