-OEChem-02171214062D 39 41 0 1 0 0 0 0 0999 V2000 3.7934 -0.6188 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 5.2223 -3.0938 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5079 3.0938 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 1.6500 3.0938 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 4.5079 0.6188 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 5.9369 1.4438 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 6.3494 2.7133 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.2223 0.2063 0.0000 C 0 0 3 0 0 0 0 0 0 0 0 0 5.9369 0.6188 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2223 -0.6188 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5079 1.4438 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5079 -1.0313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9369 -1.0313 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7934 1.8563 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2694 1.9287 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.6043 1.9287 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5079 -1.8563 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.9369 -1.8563 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.2223 -2.2688 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.5244 2.7133 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7934 2.6812 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0790 1.4438 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0790 3.0938 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3644 1.8563 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.3644 2.6812 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.0183 0.8796 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.8038 0.6761 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.4182 -0.0699 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.3156 1.3305 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.8500 2.3411 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.7951 -1.0041 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.3837 2.0573 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 7.4410 1.7867 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.7758 -2.2789 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 6.6606 -2.2978 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 5.4830 3.5806 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.9439 0.6110 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0520 3.9412 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.6312 1.4351 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1 12 1 0 0 0 0 2 19 1 0 0 0 0 3 21 1 0 0 0 0 4 25 1 0 0 0 0 5 8 1 0 0 0 0 5 11 1 0 0 0 0 6 9 1 0 0 0 0 6 15 1 0 0 0 0 6 16 1 0 0 0 0 7 16 2 0 0 0 0 7 20 1 0 0 0 0 8 9 1 0 0 0 0 8 10 1 0 0 0 0 8 26 1 0 0 0 0 9 27 1 0 0 0 0 9 28 1 0 0 0 0 10 12 2 0 0 0 0 10 13 1 0 0 0 0 11 14 1 0 0 0 0 11 29 1 0 0 0 0 11 30 1 0 0 0 0 12 17 1 0 0 0 0 13 18 2 0 0 0 0 13 31 1 0 0 0 0 14 21 2 0 0 0 0 14 22 1 0 0 0 0 15 20 2 0 0 0 0 15 32 1 0 0 0 0 16 33 1 0 0 0 0 17 19 2 0 0 0 0 17 34 1 0 0 0 0 18 19 1 0 0 0 0 18 35 1 0 0 0 0 20 36 1 0 0 0 0 21 23 1 0 0 0 0 22 24 2 0 0 0 0 22 37 1 0 0 0 0 23 25 2 0 0 0 0 23 38 1 0 0 0 0 24 25 1 0 0 0 0 24 39 1 0 0 0 0 M END > 0 > 0 > 46506017 > 2 > DrugBank > DB01110 > Groups: approved, investigational Indication: For topical application in the treatment of tinea pedis (athlete's foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor. Mechanism of action: Miconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Miconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. > DB01110 Daktarin Femizol-M M-zole 3 Combination Pack M-zole 7 Dual Pack MCZ Micatin Miconazole 3 Miconazole 3 Combination Pack Miconazole 7 Miconazole 7 Combination Pack Miconazole Nitrate Miconazole Nitrate Combination Pack Miconazole-7 Micozole Minostate Monazole 7 Monistat Monistat 1 Combination Pack Monistat 3 Monistat 3 Combination Pack Monistat 3 Dual-Pak Monistat 3 Vaginal Ovules Monistat 5 Monistat 5 Tampon Monistat 7 Monistat 7 Combination Pack Monistat 7 Dual-Pak Monistat 7 Vaginal Suppositories Monistat Dual- PAK Monistat IV Monistat-3 Combination Pack Monistat-Derm Novo-Miconazole Vaginal Ovules Vusion Zimycan miconazole > DB01110 > http://drugbank.ca > http://drugbank.ca/drugs/DB01110 > 4189 1 > 1 3 $$$$