UCSF NMR13CXXB=2DBF1HEECC!Y@ljȗ D&HuQIH*H@HJFM+X9ȖE{+ɞiɆGȧD$HHVdHSId7$I,IuINHRHoI"IGg$ȀԂH+H!hGB@H8HS1I2H Ʀ@Ⱦ$Əݨ6<ȚḨIIH6Tl2\Ȑ"GICfIO+TIHHI@ʞHQȴ;Hچm>QPFبH^lHDѻ.{]2qT040He H+rHdLHQ9<́2/Hƫ;t+I I:I< HKxH&IHvNjȈ$nȂ$%zH}BHYHsE q\,ZlȶY9(i!nG#H̑HN>J0ޤ.57L ?kVD$ȟPG/IJIΎIIZIHH_II>Ip ȣ0GrHHçH f H<&Gu ?ȰH-I BH%xGMVHM@H HI6IppH%~^pSSH2CI{I}H|=HԒHHGhF|PƋON'"YWżuƹxQE<|!ȫ4HvIM*rI&ǹwMZ3(ɇ-ɑ{xVjɫ{ɖɍ"ɀH# HI|H,Iv>I[ILI-4nHH aȓ*HnH$HvBHHr!DŽkHH I(JIYeI@i>HXG|ǯ8HWC.HؗF$ Hd)HQHUfyG ǬKvi y NȟdE~qjwmtG:#.PzF*Aw:A 3"zH~I"H"&GȧBZ6LNQɛLsɍ{*~EHI[ IcIJI$RIZII\IwH2͚IErH$rHTHVImIgHz e8ȀGGNHOCn4ȋ[ȑkGHG*2*~ކZWI `IW›H.F0L1"{^rǕk`ȏmWsHkH`4HHHX..xHP+Lh:UrIVqJDJsJJvJJJlJ#gISH 2IN,HGov^xHIHmM`Y mIlIH9pI- IagLjVɳ,DeIh=PI{8I"H0Gdj?:4HIu~I.Ho0<ȤJFJBϖIuIb7=JJpfaʭʅqXJ8KJͿ|tʄ[iʮz JҰvK&;K)J%a*rI&JΰJ}cI=ɠa2˃H5HHHrǃ-`(wHIHƞH*H/I0IhH!"F@HmI&=+Ω":-bh^dɢwkт8歂JE~GK$:KFL"zLiLLӧL{L58KzKaJdJX"IFIlpI|`J'JV_I!P4f JhKeCJVɫ05ʀeJ 0KK8ОJyX^IJ]J4IxֿP/HqHHxeHIEHFǚHImIIE7I[lGǹGbǒDȃ[ȉOȃ|VI/ HJT&,ɢ@0jɎwEIIJWJ۳K>KJJVJvJHInIVsI98I.HkLPIlLIjIW!HhIȪI"IGhHBH*Iȼh<ȆI&6I50IκINIP"I8nHpȥcVJ&`WJ2tI_IhI&`II6MIH͍YC<5~6H/uIpIDQ4xȪRGrJ -0=`HIdUIOcF^&q"FFL)@ȢHɦr_^`ȔIJ:IXI.I18Ȕ:ةsIȳȎ4Ȃ>zƇHFE@ȁ%3T`ɤdɈXȦ7HrJQJ JIPɉUrɢ ɰɍpH5jK]7l@ȱHdHG-ɃJ5 KTKL%^LDvLv KKBhJixJ0J XIIzI~I7pHӬI3$IIj@CJ}HDŽGTip<  f.>F5ȹэȳ:0$mjw!ZȠzi\>n~xwIp"VkDhuȖFlI!˼HH?Gz|H {H8H2IWjIHyH}H+Hn1hɄɳɩ> ɃDdȨna ȶ%7V/ -UN[ɁF/dIsIIIPAHCiHv%}4XȾ HgTIICIfI]GϘDŽIHlAH_QZF݅dI rIHȏȿ HAHHTGgG 'ޘ&ȈİxA& ɤNGIIII0I+IBH$ȩȢ ȒDȃм;XF-JvȦȌǸFHK5I"I=gI)HrܾGjtHPHMȬͶZIn,]"\QU#&"Ȇgȁ72C% )H},HޞIHzGHH!KH2\U`HpIf_%Ia:HjFn HbHIHȋ4p˰ɚIɘ~8ɥRI\1I6&II`I`I+IHNHMH< S/Ȩȷ{G0IC=Ik IiNI%vG A!+Ȩ lȶfHsGL*'7EH:%JρȨY&/xɋ`ɞ, < Ȍ]_tl I"QI] I8H++<ȲSȗnHQ2\I>IWI#mI&HF`@GlGJS*7 X=ɇVɒVɷ 4ȡxHwI*~I$I*BI5bHHRI-RIQ-HOMhݚ~ȽPȲ;ĥGjs0II!#IHH"HCy/Xȑ-FH 5GaP.nɩȇNȱfəɶ@(&wb [I)IY H ^FV\+nHIfnIa_IkII-}&G șȵhg8%Ҵ~J:Dn%'pS*^I3*ɖɃAȬUȔC(bH]7IφIHXBH %GmHeHכH |D8oH\sȤE(@HIH(GHZWHk G6|@-+FâHC=4H&uHiH,, ǑƯF[ȑO5¡?ȿ;ǝfF[#, RȟHH}qHmH$jH$QȔh%ȲE4ȭ@HZJPIyHVe˄[%3n94H(IGI?G!ȯ#yt'4ȵ@ NIVKϳ{zȭnG8lGxfHH2HuGHzjHGjR9HDOII Hl.k soId}ȡH[ICI)R$cnȝO ǴGKBHӥI%HHkȫдu0G݆HͱH³*u@HH=Eȿt۲ȃڂȕE=uoŅHKG[H4HtIHH#ϑM=ɀɓQɘt.Ɏ-|dGfHHEIImH3S'HDIHafHHltHGH !lHQI ,H7 A/غT 7xn4%Bɉy*yG$G哞ǟJȨGGPH/II&B+ڕH8HxpɂwIW**?6H-tG3ȧGƻ`^HI zIMIih#I8HVHQS O;.^AvHHS/F|/dɔɄxȀіHHqvbC&HЊIVI@HB^8$`1 (t bȶzWh=UɖIxGփH4ǠpȌ5Ȟ-GExIGIZI?cGJ O;~,sHC"Vt,ɕ6IEHRȤ3HG,+*(Ȅ0@)@"/BHXI uI0IHHtH<%F%sȷGk I4tyI#'ȼgpH)O=TȁrH H |HTHGȬ8ȧG| ȵFJ`HiiQHlH2GxxHBH]AHGJHtF4+.THoqI8HHxHG-C}ǁp(Ȍ;IjG`gHmGHKII ƱȆd 0XGaH g ֽ{;U ȼRH1HJCp,HPlH9GR_0GI !IIIr7HHJȢH0t*BH͇6IaHo^X׀M]4Ȓīg3ɂVGTHH{HYG;8GzP H¹I0\GnHNIHHȵHfGH0HrHH"glG`G^ p$s'XPQH,H"G Ȇ16Et W@hȔꦺ78YȬPQ>H,Hq ?bFXn0HΘI[I|I;GSZWȡG5ٞ4̒H'1I ZG@6L"ȠN 9p}>HtE_ɡGOUȧH II'ICI1IzLH HG"eGZ<Ȑ`#{HKHfJH}hHɈ\HI ȱFGT<ǠNwO_9.O~?ɖ^ɤ|VХHHG,J'na]H% IG n^HI/A H} DzEBH*GfzS"Ƀ)ɦHH|Ȼo>>,ɒhFrFޢóGNY׭ GqQHHQI"I-jcH4HIG4+sGWxHH*HgH#6IN)QFyvH\eH;uHCHHpyXBpcOGm\ȍ\)H9VHrHI jH< GDHH,oHm3HQ\HqH~KH rGZ,I=I2~HLG Ȃ YȤD3_tDKQ(%,V_M} ɂouH݂IPGHIގHCHHHkH|[K H6H *H$|6HNnHi'ƫVE%ǖtHH,HNHįnI'ZI ,lHHQ`H~HH^Ȇ؉߭ șƏPHKǞ\>_H[I"gHm\GnH|GiGWpG(X]Xȫnj HHhHTlHZGHDI!=XHlGT`Ɗ@@ǰ ,F G8MGȩHG\!3L\HEsI@0THzGH,H!6HH 7FEGGW\DY2Hv:H>HsH HZHGAVCèHoMIF+=ICaNIXWI |HHAxșy$yIJjHGiFhHH~bH}2.G:NdHJZ@ț%hQkȖSdIIeHs.LȅHLHvGaUsDZLHB[KȀȀX>Ȅȧ J&D$8GHsINk7IXrH#NH>HFHiHk%FɂEsHKnI0ImH&Hв2Ȟlm`jIfZIeI^I8rHkbG`*ǨȠLȚFH I&'CH_?H`ƨ*ȊҢ$G+I$lj5KWȫb %ˆ Hg(YHH)I *HaF`EMȍ1 ǻoH{@ ӡBH HIKU?I^ۀI&}Ǔx,M lȐjǏP#}HרIFsIHGӹȩȊ9{XHo I,pILǯwc@THsI&c2I/IIHlHǴGpF`GVTa=fx8%H8HQHoG1HLHH4#sH/IN1HHCTurȑȮ`&=҂Hv)H%KǗGGGG=ț(,<,<wF{HGLHH@.HȪGjKȟ~aG54#f܌.HbI1EIoLG%p:(GVҰl`VȜHIKvIcRI".HF$HȈȚT> HH'HH:zHH HH)HIU+IrIVG>k@q@LJGZ/EȺOHJ I)QH>G4#HEH[II/|HٳA qHRI/qG;]ȣǢ`&ȷ6h.H-I4I-nHHkǔ8u*rDaK>H(HQT<8pȈȳvFHH)NH$H8HCHIP)IfH`PGydHHGjǗ30I"gIeGHI IqH׵H IVHGDɩ"ǭbI9@Hpdžlȋ._E2ȃeHȊd;{GVtsɍAɝ1RȟHI].IǺWȊDǀȪ@1ǝDȊoGYG4Yr6ߥ&"#)ȇjH^G0ɔɋ9H3GdH-bH5U"GcHI hH3H DH.]H́HǙż @Ƹ0H0.H)II?tIGHiȼxW\#c ǿ\HzHTXYgȪxH?}H2\Ga }PqpFɕvɄShH~H8 HNHp,/Hh0H Hx5HH9fG.jșfɆ/ME(vDz PɃ8dGI>iLIF`dF GHRI PHϢHBXGH~AG] 5Xȧ~q4rHIAfI G°`a`3\1G֌H $iǮl|u,FuHIH]He~b-^frH G+2pEǀHHtI#JIGITIIHEmGjGhHFGx1JȡfGNJ/'Ll$$~SȈHc(IG~IIy#HLM:$HIH(GljY~5I'E u@x>H Ǒ)t$h ˚ ǟp_s70J"X,H%Hvo]5^Ȱ^TH]H%HmGȊtȄ!H;H$W8[ǪpG"H`&HI I@I Éȏ&1)fs|HMIQH^zGtpHN%Ȁ,2/M'GȽ*hHI%.IHF\Im I-h[@ȏ)ƗHꬒIiEI9wHK6FLȏnm46T ȿ}NFU=h§7iȪlȋMtS͏I%G65*Q*jyȉPǖLH+I}H\HC΅GܸH8THH!`J]PXFHNHG/ .lyȳGHkIYH_fF`FȥU ٰ| ȊH WI`IHF~^@HH&HI"H(bHLI|I{RIgIHڷII8HUhHIHJȇc?9/ ơUI"HQLkJHMH#ATrGI.Iw@HX'TheȼH=IK^HlPl.H+ II,HN6_@ȺsH!F JWȋdž HUIL&HdȒ@XȕъGHsHVHNHpHpG, ;I@ Hr`Ij IsO I`pIbII-I*H*I.+IYICrKI _I =pH}dȄNS.G?6IIC\HGLHwHH*BGHhII9AI I=̟H?BhFt,H'&Gl2Ů pHPHn9H͏DHeXȨTeɄqȰpHP))ȲQǠX~rhH9iHۦHXtd'04D{ ȩbǙMHImVXIW*IiHI&?eI2IWIAoFŹ@HHm(ǫ0HI\(I.IF9ITI&iI"MI NI6TXIMHIHQH8JHIpIG 3`YB!v*3~ȥgbThfŻbHHN2ȃ& ~G0FڷtFI@I.;HQ|xE8HSKIU[IHSto9%;Ⱦ_ȍ}HCJH'Vȳ~PȽ8E G ȓHIbI,IqNH|IsIeWI/oȧ~nȒxU5hGS5@I;IIfHnȬX?FHI-MILH yqLj$L <ȶGj,HŹ@G`ȓ  $LcGUNgPLȃ ǶH H[rȁWR8鎸ȝHUH*";jb!|H I H#]F5 @vFt=GuȥF.GZSPaNQfHGsj<ǚtD‹HHHɊ6 Kp&I}IXI͒ǀ`ɂ7@kǓH`IqH];U Ǣ`G^=Pȃ HߕI H8DZpȌ  plȩY5H&HG"Ȇ[^2 ˴1h i'H9FqHHHSĒǜ=ǝGi#+ <ȿȏH@H@e:smuf*E(`H^HGxXȁƠ)ȷ+Jǎ;k; Ls@ H=Iǡ8ȍ#)GGHν|I HyF G0HcH4H]F~1pG3?8HyIIԎIkGȴHW}HxHWmHsZHFLjfȳkPmO1ȐҧȚ~ȏvjPƮFD(H'ȹoU:O2["٠Ș0FW0G'!p8hFkyZrG-HãH=hȐɉ5ɴ'4K'_H[;HoHX8H FNpHuKI0IB;$H_HzIBIOIvIϪII?{XGHw&HWKI IH#_HMH].GjaVɽmHb egȼ*2ƹذȺUZJ$sHHHȶ?ȣHoz}'/uSKɖDɊ sHHY^0ȧ~ȕJG+„HIH^{D ɋܥoȬ8ȐjhXHǰIH-bIII4HE *93HKI&HHIJ]IiHHHHH_@HNG#(ʢFmHy"g@QG1pה!DǬoHgVH" 0fIl(HN$IIGݒ8EHLH'ȳF5f@ǑsHA(:H?bHOH"aH8aB;z6@EHWoH|ΟS,(M6>y' Ț HiH[Ɉ]46[Ȓ)+ lȒAB$IqI$~H%H cHcGvKȄ;.H!H(QH|EG:5ȺXHyHJU zȿ_Ȧ6H5I:IwуIGfI&!IIHΫȩj JHPI3/HXGlǕ3HtIE0HRsXG>HDHm`MB'FۀHEWȃ\H Dp_IF԰jH C Xȸn[(.:|a:H[^I;XHHmQGXHֽȀDlHQCH<9JTȹ+~H BIUIGI]mIqIDIɰIPNHI RZH^X.XH܄I_lI tG&G HGVDȋX}ȭ\XKH I0OH Ⱥ+1yH|H\)[%H9I1tbI`Hȓ|6nŰI>OI*enH6H_HH#GĔWȃvE.)ȴoOyȇȍ(H?,I<TIDHHG}JX$qnH;rVI HVIS1I+IHI~sI^(.}\ npȥllHIGH惜EFJq%lt34ǗH IKI:enH8'.:I IH|RH09G j@HR“H#@QǮ_XcoȅZoGTFŬHxQH.jbH1H!XH}IIH$H^ bȜfH)XH'Sa gȄ_baHl:IALI HǨĔHw>IuH(] G7:HAI;2IYH'o7ȍGlȄ|HԉX!ĈȉnE^, H5HI I+^IG"H7HH̫>H$HI>HpȄFpHHIH HJmF^ljȌ2,HBuHvI"* ICI0AHGȩ%dc]KȞ|pH*IH( ș:HI IaI",H$fȣȎ(G:HFaHs?Ȳ~QXMHEHHuG@@HSrHH?:H=^GjI69IM-HƮ ȕ3_RAnH?#Hp~H8&DGevHz~ȗ( ȱl HaHutȞUTG3 G+F|nȃ0Gu!%MHsdHT=G{HƗ^9ȃ=ɹN8ԘȐy> H`bHbH/HHHH@ _@`PLHiH"(ǂ=x kȀG:HźHJH)F`,{TH(H RHQHjI$I *8.ȁdmSR{#FHII)G;FȄ >ǘIHfHVx,ޡȈ4VmH>HHXAHȽIInQUF"QH|HGa3=kC2s/?ȝHV+HQ:Ǚ9ܱF.IKR[nɆ`(G I|HVHwF$ƛpʐHZH`hHj(j=GD|ȊHIH߯HPsHIIlI,,I0I'NG_GǾHRIQ<6IElHX>H'H=aHcHf2gA8wHBHo,GfkƙH1+rEeȳ?BHIofAIjI(IEWIL^G:#I"IHS(2ɤVBO>_FH>Gk 3eI.X|/xjmG@HokXHkHjH*kG#ÇNHd1BYG&G|H$tĖ0zHGp8IJI':HHSI}IAI.BHyVH,?bpGQ̛dmywGRbH-rH$HX[Rub kRH*HHEHHrA n4IQ9I IkHJ8dCLJHiIIaHɚ b~HI3IH[0Hxz P1>{H@ș8Ʌ9ȥ#F@HGf:Cv3{HxCHɔHʔƲHtTH[ڍ,`^I HކeIu{HHI*HGZ KI!8HesH(HG͹ b=Ƞ6HIHI7" I'`FE%XGFH@ҝȆH`I^IUaHNJ&HGSGBHyIY%I,/KHUɎ7HotIpIIHw;lHOc#ȱG_DH&k']XRI9AI3HxőGvǝ7R֧J~jȥG 0HZH {HnHGHr'+IFVF 7@HPHGZȔ<H|H뇳I'IKEZr$FsxH6}HGIsXHAHHHG^6HFGȡD*ș]ȱފȻeGHWH׈6H+Ȃt$=KsTɎHB`7 SDG HN HRHfpHkXH^HDžOj /ȈqE!c MȻIZpIYHiL8ɕ#Ik`ɄHI6SI@I lH: I`NGIH ȥ UGq~+ZHiHvG)HGIˑI#+H;GË5Hk\Hs1QHHǶ.QNIF(HqHzjn@V~22~EEDqPGaHm#I6G:G%YI4I"G"vH:2H[t"H[Hx#QH[HHy[ȠzjN99tɎaMɈɅ vɀ2h1(ȶg 3ܦH=(VG~`6nHVG4) ]M-1I=JZJ 2lZ I[ЄJ>DJFJHtIP|q+'ȶ,J>tI,GIBIϟIrV>Ɇ$IC*IxIQI%,G HF-,H-޸^!]ȁc)H~PHt;9;HlIZHJAHW#HL~HI )HPbj5^-(R H|G#MɆh HɲȷaHIdHGHH,ȜDɗȁ0}I](IېIųɑ,3Oɜ)IJ؀JuGYI}2Y ݷIa"IIrI%ɡj(IEZkIdu!HSH0H- H$Gк~4_o y@ȔwlȣȢȠEn I.Ŧȡ[7GQzv|ɥaxɅrupRKɴ ZڷG{(IKJNW+JINIṘI<:-0|U-vI4_JKj=KKK8K K L+L/L-6KbnJGIJQK}L,K/BKL6LbK0(Ky[K2:lKtK\̌J)IIS InIwaILIIάIZI۩JIIIIy3I(HxIF!%.ɩ|"5GrS$F6ɱi#Uh9t$ `ar@+ʩh4GKbJKǾKT^JL5RVK9KLL@L]LLlKJRKtLGbBLLLLݙLLnL nKP(L40LKDJJhJ0XJJ 8JJ$JN'J`CJVŜJ?ѲJ"dIdI6/H΋zG"uRN^- Z5>1}s VyTMwʐ=ʍIJ̀JpJJ>Lɵ{[Qd#ɋxty4;J*pgJ@J8DJfIJK9Kk߼KeJEKJIU\J+K$JK9 JͺK#gKU,K'qJLJ3JgJJ>IZIXIR^IZDII9INVIB9CIfIG}_GvHW8HI#^IH(GNGajH8)L\>+͌H2@H Hf2HܧHdW~^VȃvHF0H)GHtHҮJ]J81CA|ȧhȫ]bzIcJQJBO& ^\ʁ,z#BJMGJd*I\rm>Jnɳ~= ȖH>I' DIVI:ChHzI(xIH`I0HUF(H>Řp KȓmȇRHHFH¡5ǎHHHu G iF0HsHZG2H^I~,HHrHX,HHCHr H!YCHDdHpH%^GrGG.ίVɌ-ɽɊWC4HMɶ ?K॓ȽxI0J@jI?*KOxɌjIHOIZKJNCJ.IRIKzH.lII}IH,HoPH\H:JHF @vZzHK~ɀNyI\ /IXI*,ȬWH6bݺRIHGI@E,ҀHHvH7IH4H#qG@II:/H֪H9HoHD/eH&4HǑXǔGoGùӌɯ~nH8#I<+\XݤJ7`G~HȍH{MIIVHr