Structural statistics: str target upper limits van der Waals torsion angles function # sum max # sum max # sum max 1 16.79 79 26.3 0.70 14 15.0 0.39 12 181.5 26.48 2 17.92 84 24.9 0.94 19 16.5 0.52 15 209.6 28.94 3 18.59 77 26.8 0.92 16 16.9 0.41 15 170.6 19.13 4 18.65 76 25.2 0.91 20 16.6 0.46 12 208.8 27.01 5 19.04 91 26.4 0.81 16 17.3 0.55 14 225.3 30.06 6 20.09 89 29.5 0.84 19 17.7 0.41 15 193.8 20.67 7 20.29 73 27.8 0.84 11 16.8 0.49 12 203.2 31.18 8 20.95 89 27.1 0.77 19 19.2 0.49 13 212.4 31.61 9 21.08 99 30.1 0.84 25 19.9 0.45 17 219.9 21.76 10 21.27 81 28.7 1.23 13 16.7 0.54 16 202.3 20.04 11 21.50 87 30.3 1.03 19 18.2 0.47 14 177.0 15.33 12 21.58 79 27.9 0.84 25 18.7 0.44 14 185.4 28.04 13 21.65 88 30.4 1.27 20 17.1 0.35 14 179.2 21.79 14 21.94 83 29.7 1.26 19 17.0 0.33 12 197.8 35.36 15 21.94 95 30.5 1.13 20 17.8 0.57 15 194.9 26.22 16 22.12 77 27.8 1.20 24 19.2 0.55 13 198.7 27.75 17 22.22 86 29.6 0.80 25 18.9 0.57 14 199.6 23.40 18 22.24 84 27.9 0.83 19 17.9 0.42 16 243.5 28.38 19 22.46 86 28.8 0.82 25 20.0 0.53 16 200.3 27.55 20 22.61 93 32.1 0.98 19 17.3 0.37 15 201.2 28.30 Ave 20.75 85 28.4 0.95 19 17.7 0.47 14 200.2 25.95 +/- 1.65 7 1.9 0.17 4 1.2 0.07 1 16.9 4.80 Min 16.79 73 24.9 0.70 11 15.0 0.33 12 170.6 15.33 Max 22.61 99 32.1 1.27 25 20.0 0.57 17 243.5 35.36 Constraints violated in 6 or more structures: Cutoffs: Upper distance limits : 0.10 A Lower distance limits : 0.20 A Angle constraints : 5.00 deg # mean max. 1 5 10 15 20 Upper HG2 GLN 81 - HN GLU- 90 4.83 8 0.08 0.29 + + * ++ ++ + # peak 209 # SUP 1.84 Upper HG3 PRO 46 - HN PHE 60 4.54 14 0.21 0.68 +++++ ++ + ++ +* + + # peak 325 # SUP 1.15 HN PHE 60 - HB ILE 61 # SUP 4.63 Upper HN ASN 65 - HD22 ASN 65 4.37 15 0.20 0.35 + +++++ + ++* +++ ++ # peak 417 # SUP 7.06 Upper HN LEU 50 - HN HIS 51 4.05 18 0.26 0.39 ++++++++++ * +++++++ # peak 429 # SUP 5.93 Upper HN HIS 69 - HB3 PHE 70 4.90 9 0.10 0.27 + *+ + +++ + + # peak 491 # SUP 5.61 Upper HN HIS 75 - HB3 LYS+ 76 3.79 6 0.09 0.26 + * + ++ + # peak 519 # SUP 6.38 HN HIS 75 - HB2 ARG+ 78 # SUP 2.19 HN HIS 75 - HB3 LYS+ 77 # SUP 4.40 Upper HG3 ARG+ 78 - HN LYS+ 80 4.05 20 0.50 0.77 ++++++++++++++++*+++ # peak 551 # SUP 3.79 Upper HB3 ASN 65 - HN LYS+ 67 5.07 7 0.08 0.24 + ++ + * + + # peak 569 # SUP 3.62 HB2 PHE 60 - HN LYS+ 67 # SUP 1.35 Upper HG2 LYS+ 77 - HN LEU 79 3.86 20 0.60 0.80 +++++++++++++++++*++ # peak 578 # SUP 3.28 Upper HN LEU 79 - HG LEU 79 3.92 16 0.35 0.55 ++*+++++ +++ ++++ + # peak 585 # SUP 8.29 Upper HN LEU 79 - HG2 LYS+ 80 4.01 16 0.24 0.50 +++ +++ +++*+++ +++ # peak 588 # SUP 5.99 HN LEU 79 - HG3 LYS+ 80 # SUP 6.26 HN LEU 79 - HD2 LYS+ 80 # SUP 5.28 Upper HN ARG+ 58 - HB2 PHE 60 5.04 19 0.51 0.68 ++ +++++++*+++++++++ # peak 661 # SUP 4.46 HB3 CYS 53 - HN ARG+ 58 # SUP 1.08 Upper HN GLY 48 - HA1 GLY 49 4.54 6 0.14 0.77 ++ ++ * + # peak 694 # SUP 5.29 Upper HN ARG+ 52 - QD2 LEU 82 4.28 7 0.12 0.83 + ++ + +* + # peak 737 # SUP 2.08 QD1 LEU 50 - HN ARG+ 52 # SUP 1.55 Upper HN ARG+ 52 - HB2 LEU 79 4.42 19 0.46 0.91 +++++++++++++++ +++* # peak 739 # SUP 5.63 Upper HN ARG+ 52 - HN CYS 53 4.23 19 0.14 0.18 +++++++++*+++++ ++++ # peak 741 # SUP 4.52 Upper HN ARG+ 52 - QD TYR 59 5.25 6 0.08 0.48 ++ ++ + * # peak 748 # SUP 3.13 Upper HN CYS 53 - HN ARG+ 58 4.60 20 0.50 0.92 ++*+++++++++++++++++ # peak 757 # SUP 0.67 Upper HN CYS 53 - QD2 LEU 82 4.81 14 0.20 0.82 +++++ + +++ ++*++ # peak 761 # SUP 1.02 HN CYS 53 - HG LEU 82 # SUP 2.46 HN CYS 53 - HG LEU 66 # SUP 0.75 Upper HN CYS 53 - QD PHE 60 4.70 12 0.16 0.49 * + +++ + +++++ + # peak 763 # SUP 1.44 Upper HN ARG+ 78 - HG3 ARG+ 78 3.95 12 0.15 0.35 + ++++ *++++++ # peak 767 # SUP 7.61 HG3 PRO 43 - HN LEU 45 # SUP 3.15 Upper HN TYR 59 - HB2 PHE 60 4.95 20 0.57 0.72 ++++++++++++++*+++++ # peak 821 # SUP 8.12 Upper HN ASP- 44 - HG LEU 45 4.98 18 0.38 0.72 +++++++*++++ + +++++ # peak 844 # SUP 3.78 HN ASP- 44 - HB3 LEU 50 # SUP 0.26 Upper HA VAL 84 - HN GLU- 85 3.44 6 0.05 0.17 *+ + + + + # peak 899 # SUP 3.00 Upper HA GLU- 40 - HN PHE 41 3.32 15 0.20 0.32 + + +++++ + *++++++ # peak 931 # SUP 2.97 HN PHE 41 - HA PRO 43 # SUP 1.36 Upper HN PHE 41 - HG2 ARG+ 78 4.91 6 0.08 0.45 + + +* + + # peak 938 # SUP 4.53 HN PHE 41 - HG2 LYS+ 77 # SUP 2.05 Upper HN HIS 69 - HZ PHE 70 5.11 20 0.42 0.67 ++++++*+++++++++++++ # peak 1234 # SUP 4.75 Upper HN GLU- 40 - HN LEU 79 5.13 16 0.25 0.53 + ++++++* + ++++ +++ # peak 1292 # SUP 1.72 Upper HB3 LEU 45 - HN GLY 48 5.47 9 0.13 0.61 + ++* ++ +++ # peak 1478 # SUP 4.08 HN GLY 48 - HB3 LEU 50 # SUP 3.29 HN GLY 48 - HB2 LEU 50 # SUP 1.58 Upper QD2 LEU 54 - HN LEU 66 4.64 10 0.17 1.11 +++ +++*+ + + # peak 1518 # SUP 2.83 Upper HA LYS+ 80 - HD3 LYS+ 80 4.16 17 0.37 0.84 ++ ++ +++*+++++++++ # peak 218 # SUP 5.58 Upper HB3 GLN 81 - HA GLN 89 3.86 6 0.07 0.38 * ++ + + + # peak 264 # SUP 0.75 Upper HA LEU 50 - QD2 LEU 50 3.30 12 0.18 0.44 + + + + ++++*+++ # peak 319 # SUP 4.97 Upper HA CYS 56 - HD3 ARG+ 58 5.50 11 0.13 0.30 + +*++ ++ + + + + # peak 453 # SUP 0.02 HD3 ARG+ 58 - HA VAL 84 # SUP 0.02 Upper QD1 LEU 54 - HB3 LEU 66 3.28 7 0.18 0.64 + ++ +* + + # peak 522 # SUP 3.84 Upper HB3 SER 72 - HB3 LYS+ 73 3.12 16 0.29 0.50 ++++ +*+++ ++++++ + # peak 638 # SUP 0.02 HA SER 72 - HB3 LYS+ 73 # SUP 0.02 HA SER 72 - HB3 LYS+ 76 # SUP 0.02 HB3 SER 72 - HB3 LYS+ 76 # SUP 0.02 Upper HD2 LYS+ 77 - HD3 LYS+ 80 3.40 13 0.24 0.55 ++++ *+++ ++++ + # peak 715 # SUP 0.32 HD3 LYS+ 76 - HD2 LYS+ 77 # SUP 2.52 Upper HA GLU- 40 - HD3 LYS+ 80 4.06 18 0.31 0.65 +++++*++++++++ ++++ # peak 727 # SUP 1.84 Upper HG LEU 45 - HB2 TYR 59 4.91 14 0.22 0.56 ++ ++*+ + +++ ++++ # peak 822 # SUP 0.57 HG LEU 45 - HB2 PHE 60 # SUP 0.47 Upper HD2 PRO 46 - HG LEU 50 4.21 7 0.08 0.36 + ++ + *+ + # peak 956 # SUP 3.48 Upper HG LEU 45 - QD1 LEU 50 3.65 14 0.23 0.57 +++ +++*+++ + ++ + # peak 1341 # SUP 3.08 Upper HA LEU 54 - HB3 LEU 66 3.74 17 0.23 0.64 +++++++++* ++ +++++ # peak 1346 # SUP 6.13 HA ALA 55 - HB3 LEU 66 # SUP 2.78 Upper HA LEU 54 - QD1 LEU 54 3.83 9 0.08 0.25 + + *++ + + ++ # peak 1354 # SUP 4.83 Upper HA SER 72 - HB3 SER 72 2.41 12 0.13 0.32 *+++ + ++ +++ + + # peak 1431 # SUP 2.84 HA ARG+ 71 - HA SER 72 # SUP 3.01 Upper HA ARG+ 78 - HD2 ARG+ 78 3.97 6 0.09 0.45 + +*+ ++ # peak 1459 # SUP 5.68 HA HIS 75 - HD2 ARG+ 78 # SUP 0.78 Upper HA ARG+ 78 - HD3 ARG+ 78 4.05 10 0.13 0.57 ++++ ++ ++ +* # peak 1460 # SUP 5.83 Upper HA PHE 70 - HG3 ARG+ 71 4.62 15 0.30 0.76 ++++++ + +* +++ +++ # peak 1504 # SUP 4.65 Upper HB3 LYS+ 67 - HB3 PHE 70 4.62 20 0.33 0.51 ++++++++++++*+++++++ # peak 1507 # SUP 2.76 HB3 LEU 66 - HB3 PHE 70 # SUP 1.93 Upper HN HIS 69 - HA PHE 70 4.59 20 0.51 0.61 ++++++++++++++*+++++ # peak 1514 # SUP 5.29 Upper HB2 CYS 56 - HB3 ARG+ 58 5.18 13 0.14 0.29 ++ +++ + ++ *++++ # peak 1521 # SUP 2.47 HB3 ARG+ 58 - HB2 PHE 60 # SUP 6.78 Upper HA GLU- 40 - HD3 ARG+ 78 4.00 10 0.16 0.57 + * ++++++++ # peak 1540 # SUP 2.05 Upper HA PHE 60 - HG13 ILE 61 5.23 10 0.09 0.23 + + +++ + * + ++ # peak 1588 # SUP 5.69 Upper HB3 PHE 41 - QD2 LEU 50 4.59 7 0.10 0.56 + + + * ++ + # peak 1611 # SUP 1.88 HB2 PHE 41 - QD2 LEU 50 # SUP 2.17 Upper HB3 PHE 41 - HA PRO 43 4.35 10 0.14 0.31 + + +* +++ + ++ # peak 1612 # SUP 1.05 HA GLU- 40 - HB2 PHE 41 # SUP 3.22 HA GLU- 40 - HB3 PHE 41 # SUP 3.25 HB2 PHE 41 - HA PRO 43 # SUP 0.28 Upper HN GLU- 40 - HB2 PHE 41 4.45 14 0.26 0.69 ++++++++ + ++ + +* # peak 1618 # SUP 1.54 HN GLU- 40 - HB3 PHE 41 # SUP 2.14 Upper HN ALA 55 - HB3 LEU 66 4.43 17 0.37 0.74 ++ ++++ ++++ *++++++ # peak 1638 # SUP 3.65 Upper HB2 LEU 79 - HN LYS+ 80 4.41 9 0.08 0.16 + *+ ++ + +++ # peak 1660 # SUP 7.81 Upper HB2 LEU 45 - HA1 GLY 49 5.50 8 0.20 1.27 + + ++*+ ++ # peak 1693 # SUP 3.96 Upper HB2 ASP- 42 - QD1 LEU 45 4.21 7 0.09 0.43 + + ++* + + # peak 1702 # SUP 5.60 Upper HB3 ASP- 42 - QD1 LEU 45 4.39 8 0.12 0.77 + * ++++ + + # peak 1706 # SUP 4.74 Upper HA PHE 41 - HB3 ASP- 42 5.50 6 0.05 0.18 * ++ ++ + # peak 1711 # SUP 4.14 Upper HG3 ARG+ 78 - HG LEU 82 4.61 10 0.16 0.58 +++ ++ ++ *++ # peak 1734 # SUP 0.96 Upper HG LEU 50 - HB3 TYR 59 4.91 15 0.54 1.26 + + ++ ++++*++++++ # peak 1768 # SUP 2.50 HB2 ARG+ 52 - HB3 TYR 59 # SUP 2.87 Upper HG3 PRO 46 - HB3 TYR 59 4.48 9 0.17 0.64 + ++ + ++ + *+ # peak 1769 # SUP 4.39 Upper HB3 PRO 46 - HB3 TYR 59 4.94 11 0.20 0.60 ++ ++ + + + +++ * # peak 1770 # SUP 2.47 Upper QD PHE 60 - HB3 ASN 65 3.49 16 0.25 0.47 ++ +++++ + *+ ++++++ # peak 1790 # SUP 4.04 Upper HD3 ARG+ 52 - QE TYR 59 4.10 9 0.13 0.83 + + +++ +* ++ # peak 1879 # SUP 3.00 HD3 ARG+ 52 - QE PHE 60 # SUP 3.35 Upper HA THR 68 - HG2 ARG+ 71 4.65 6 0.07 0.36 + +* + + + # peak 1885 # SUP 2.99 HD3 LYS+ 67 - HA THR 68 # SUP 2.78 Upper HA THR 68 - HA HIS 69 4.13 20 0.54 0.60 ++++++++++++++*+++++ # peak 1891 # SUP 4.57 HA THR 68 - HB2 SER 72 # SUP 1.17 Upper HA THR 68 - HB3 HIS 69 5.50 7 0.09 0.25 * +++ ++ + # peak 1892 # SUP 4.66 Upper QE PHE 60 - QD1 LEU 66 4.16 16 0.23 0.44 ++ ++++++ ++ +*++++ # peak 1907 # SUP 2.45 Upper QD PHE 60 - QD1 LEU 66 3.78 17 0.30 0.52 ++ ++*+++ +++ ++++++ # peak 1908 # SUP 4.34 Upper HA GLU- 40 - HG2 LYS+ 77 4.40 17 0.26 0.50 ++++ ++*+++++++ +++ # peak 1931 # SUP 1.58 Upper HB2 HIS 69 - HZ PHE 70 5.50 12 0.19 0.47 + + +*++ ++++++ # peak 1945 # SUP 3.91 Upper HD3 ARG+ 78 - HG LEU 79 4.09 13 0.24 0.61 + +++++* ++ ++ + + # peak 1951 # SUP 4.15 HD3 ARG+ 58 - HG LEU 79 # SUP 0.02 Upper HA SER 63 - HG LEU 66 4.34 12 0.11 0.31 + +* ++ +++ +++ + # peak 1967 # SUP 3.33 Upper HA SER 63 - HN LYS+ 67 4.75 11 0.11 0.25 *+ +++ ++ + +++ # peak 1977 # SUP 3.13 Upper HB3 ASP- 42 - QD2 LEU 45 4.33 7 0.05 0.17 + + +++ * + # peak 1995 # SUP 5.90 Upper QD1 LEU 45 - QE TYR 59 5.33 6 0.11 0.82 + + + + *+ # peak 2002 # SUP 2.00 Upper QD2 LEU 45 - QE TYR 59 4.45 19 0.55 1.13 ++++++ +++++++*+++++ # peak 2003 # SUP 2.00 Upper HN ALA 55 - HB3 CYS 56 5.09 19 0.33 0.52 +*+++++++ ++++++++++ # peak 2010 # SUP 4.21 Upper HB2 CYS 56 - HB2 ARG+ 58 5.04 14 0.18 0.33 ++++++++ +++ + + * # peak 2020 # SUP 4.24 Upper HG3 ARG+ 71 - HB2 HIS 75 3.67 6 0.06 0.26 + + + ++* # peak 2027 # SUP 2.37 HG3 ARG+ 71 - HB3 HIS 75 # SUP 1.66 Upper HB2 HIS 51 - QD2 LEU 82 4.42 9 0.12 0.42 + +++ ++ ++ * # peak 2030 # SUP 2.30 QD1 LEU 50 - HB2 HIS 51 # SUP 3.22 Upper HB2 LEU 45 - HD3 PRO 46 4.19 6 0.11 0.51 + + * + + + # peak 2061 # SUP 7.21 Upper HA1 GLY 47 - HA ILE 61 4.09 18 0.41 1.23 ++++ ++++*+++++ ++++ # peak 2077 # SUP 0.97 HA1 GLY 47 - HA1 GLY 49 # SUP 1.84 Upper HA2 GLY 48 - HN LEU 50 4.87 18 0.41 1.03 ++++++ +++* ++++++++ # peak 2085 # SUP 3.57 Upper HN LEU 50 - HG LEU 50 3.85 14 0.22 0.57 ++++*++ + +++ +++ # peak 2103 # SUP 6.63 Upper HN LEU 50 - QD2 LEU 50 4.06 16 0.27 0.48 ++++*+++ + +++++++ # peak 2104 # SUP 6.10 Upper HB3 PHE 41 - QD1 LEU 50 4.76 8 0.11 0.42 + ++ +*+ + + # peak 2107 # SUP 1.58 Upper HD3 ARG+ 52 - HB2 LEU 79 3.99 10 0.12 0.48 ++ +++ + + *+ + # peak 2133 # SUP 4.03 Upper HA LEU 66 - HA HIS 69 4.67 20 0.47 0.65 ++++++++++*+++++++++ # peak 2178 # SUP 2.18 Upper HA LYS+ 73 - HN ARG+ 78 4.32 16 0.26 0.50 + ++ ++++ ++*+ +++++ # peak 2185 # SUP 2.67 Upper HA LYS+ 73 - HG2 LYS+ 77 4.13 20 0.37 0.57 ++++++*+++++++++++++ # peak 2187 # SUP 4.90 Upper HN ARG+ 78 - HD2 ARG+ 78 5.24 8 0.09 0.32 * + ++++ ++ # peak 2199 # SUP 6.42 HN HIS 75 - HD2 ARG+ 78 # SUP 2.68 Upper HN GLN 81 - HG3 GLN 81 4.13 12 0.15 0.46 ++ +++*+++ + + + # peak 2210 # SUP 5.36 Upper HE1 HIS 69 - QD PHE 70 4.59 6 0.06 0.22 * + + ++ + # peak 42 # SUP 1.97 HN HIS 69 - HE1 HIS 69 # SUP 5.10 Upper HA HIS 75 - HE1 HIS 75 5.50 7 0.07 0.38 + *+ ++++ # peak 50 # SUP 1.85 Upper HD2 ARG+ 58 - QD TYR 59 4.05 14 0.22 0.84 ++++ * ++++++++ + # peak 88 # SUP 5.28 QD TYR 59 - HB2 PHE 60 # SUP 6.24 Upper HB3 TYR 59 - QD PHE 60 4.37 12 0.13 0.47 ++ ++ +* ++ +++ + # peak 109 # SUP 6.62 QD PHE 60 - HB2 HIS 69 # SUP 0.97 Upper QD PHE 60 - HN ASN 65 5.16 15 0.19 0.45 + +++++ ++*++++++ # peak 116 # SUP 4.14 Upper HB3 CYS 53 - QD PHE 70 5.39 9 0.11 0.29 ++ + ++ + ++ * # peak 136 # SUP 2.13 Upper HB3 TYR 59 - QE PHE 60 5.14 18 0.28 0.47 ++ +++++++ ++++*++++ # peak 154 # SUP 7.40 QE PHE 60 - HB2 HIS 69 # SUP 1.23 Upper QE PHE 60 - HG LEU 66 4.95 13 0.17 0.42 + ++ + + +*+ +++++ # peak 157 # SUP 1.51 QE PHE 60 - QD1 ILE 61 # SUP 3.66 QE PHE 60 - QD2 LEU 82 # SUP 0.18 Upper HB3 TYR 59 - HZ PHE 60 5.50 7 0.10 0.75 + + + *+ + + # peak 188 # SUP 5.02 HZ PHE 60 - HB2 HIS 69 # SUP 0.91 HZ PHE 41 - HG3 GLN 81 # SUP 0.09 Upper QE TYR 59 - QD1 LEU 79 4.66 16 0.41 0.73 +++++++ ++ ++++++* # peak 228 # SUP 0.02 QD1 LEU 45 - QE TYR 59 # SUP 0.02 Upper HB2 PHE 60 - HZ PHE 60 5.50 18 0.15 0.20 ++ ++ +++++++++*++++ # peak 255 # SUP 4.89 HB3 CYS 53 - HZ PHE 60 # SUP 0.88 Angle PHI PHE 41 238.00 286.00 9 5.00 12.05 + ++*+ + + ++ Angle PSI PHE 41 114.00 136.00 8 4.34 8.28 + *+ + + + ++ Angle PSI PRO 46 122.00 150.00 12 5.91 13.09 ++ ++* +++ + + + + Angle PSI ARG+ 52 129.00 163.00 19 14.85 27.75 ++ ++++++++++++*++++ Angle PHI LEU 54 289.00 309.00 8 3.57 11.63 + + + ++* + + Angle PHI ARG+ 58 210.00 254.00 17 6.61 11.32 +++++ ++++++++++ + * Angle PSI ARG+ 58 142.00 170.00 20 25.42 35.36 +++++++++++++*++++++ Angle PHI TYR 59 206.00 254.00 18 9.28 14.98 +++++++*+ +++++++++ Angle PHI PHE 60 220.00 256.00 20 21.03 31.61 +++++++*++++++++++++ Angle PSI THR 68 309.00 329.00 20 13.00 17.54 +++++++++++++++++*++ Angle PSI HIS 69 311.00 331.00 7 3.22 7.92 + ++ + ++* Angle PHI PHE 70 266.00 302.00 13 5.25 12.28 + ++ +* + ++ ++ +++ Angle PSI PHE 70 329.00 5.00 6 3.40 15.33 + +* + + + Angle PHI ASP- 74 285.00 305.00 8 4.74 10.50 ++ + + + ++ * Angle PSI ASP- 74 308.00 328.00 7 3.46 8.84 + + + + * ++ Angle PHI HIS 75 286.00 306.00 20 14.56 19.54 +++++++++++++++++*++ Angle PSI LYS+ 76 310.00 330.00 12 5.35 10.36 +++ +++ * ++ +++ Angle PHI ARG+ 78 287.00 307.00 12 6.49 11.97 ++*+ ++++ ++ + + Angle PSI LEU 79 310.00 330.00 20 12.12 19.42 +++++*++++++++++++++ 107 violated distance constraints. 19 violated angle constraints. RMSDs for residues 40..82: Average backbone RMSD to mean : 0.87 +/- 0.36 A (0.49..1.67 A) Average heavy atom RMSD to mean : 1.37 +/- 0.31 A (1.06..2.10 A)